It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

Neurodegeneration is a phenomenon that occurs in the central nervous system through the
hallmarks associating the loss of neuronal structure and function. Neurodegeneration is …

Acute brain ischemia induces a local neuroinflammatory reaction and alters peripheral
immune homeostasis at the same time. Recent evidence has suggested a key role of the gut …

Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that exerts both
homeostatic and pathophysiological roles in the central nervous system. In pathological …

In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are
overactivated. Overactivation of these immune cells exacerbates the disease process and …

Neuroinflammation constitutes a fundamental process involved in the progression of several
neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

Given the chronic inflammatory nature of Parkinson's disease (PD), T cell immunity may be
important for disease onset. Here, we performed single-cell transcriptome and TCR …

Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Neuroinflammation is involved in several neurodegenerative disorders and emerging
evidence indicates that it constitutes a critical process that is required for the progression of …

Neurodegenerative diseases are featured by progressive dysfunction and death of cells in
selected areas in the nervous system, determining clinical presentation. Neuronal loss is …