While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …

Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …

Memory T cells are critical for the immune response to recurring infections. Their
instantaneous reactivity to pathogens is empowered by the persistent expression of cytokine …

Pathogens are thought to use host molecular cues to control when to initiate life-cycle
transitions, but these signals are mostly unknown, particularly for the parasitic disease …

A substantial number of individuals have long-lasting adverse effects from a traumatic brain
injury (TBI). Depression is one of these long-term complications that influences many …

The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between
proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein …

Effective T cell responses against infections and tumors require a swift and ample
production of cytokines, chemokines, and cytotoxic molecules. The production of these …

Optimal T cell activation requires Ag recognition through the TCR, engagement of
costimulatory molecules, and cytokines. T cells can also directly recognize danger signals …

Background Recurrent preimplantation embryo developmental arrest (RPEA) is the most
common cause of assisted reproductive technology treatment failure associated with …

Abstract CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in
humans. However, upon infection of the lamina propria this tolerogenic response is …