The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

Background Heart failure (HF) is a disease closely associated with inflammation, and the
systemic immune-inflammation index (SII) is a novel inflammatory marker. Therefore, this …

Background Congestion is the main driver behind symptoms of heart failure (HF), but
pathophysiology related to congestion remains poorly understood. Objectives Using …

Aims Whereas the combination of anaemia and chronic kidney disease (CKD) has been
extensively studied in patients with heart failure (HF), the contribution of iron deficiency (ID) …

With its complicated pathophysiology, high incidence and prevalence, heart failure remains
a major public concern. In hopes of improving diagnosis, treatment and prognosis, the utility …

Background Heart failure (HF) is the leading cause of morbidity and mortality worldwide, and
there is an urgent need for more global studies and data mining approaches to uncover its …

Abstract Interleukin (IL)-6 is produced locally in response to an inflammatory stimulus, and is
able to induce systemic manifestations at distance from the site of inflammation. Its unique …

Background: Hypertrophic cardiomyopathy (HCM) is the main cause of sudden cardiac
death among young adults, yet its pathogenesis remains vague. N6-methyladenosine (m6A) …

Background Despite major advances in pharmacological treatment for patients with heart
failure, residual mortality remains high. This suggests that important pathways are not yet …

Aims Systemic inflammation may be central in the pathophysiology of acute heart failure
(AHF). We aimed to assess the possible role of systemic inflammation in the …