Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence

S Wang, F Leri, SJ Rizvi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats

T Horman, MF Fernandes, MC Tache, B Hucik… - Nutrients, 2020 - mdpi.com
There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA)
can impact brain biology and functions. This study investigated whether moderately high-fat …

Extinction and beyond: an expanded framework for exposure and response prevention for obsessive-compulsive disorder

H Berg, RD Webler, S Klein, MG Kushner - Frontiers in Psychology, 2024 - frontiersin.org
Exposure therapy is a first-line, empirically validated treatment for anxiety, obsessive-
compulsive, and trauma-related disorders. Extinction learning is the predominant theoretical …

Cortical astrocyte-neuronal metabolic coupling emerges as a critical modulator of stress-induced hopelessness

G Descalzi - Neuroscience Bulletin, 2021 - Springer
Stress is a major risk factor for the development of mental illness, such as major depression
disorder (MDD)[1]. Despite decades of progress, including findings that stressinduced …

Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion.

B Melanson, M Wolter, Z Leatham… - Experimental and …, 2023 - psycnet.apa.org
This study was designed to explore the clinical belief that “set and setting” play an important
role in favorable responses to psychedelic agents such as ketamine (KET). In fact, there is …

Evidence of hypoglycemic anhedonia and modulation by bupropion in rats

T Horman, S Ayoub, F Leri - Pharmacology Biochemistry and Behavior, 2021 - Elsevier
Background Disorders characterized by dysfunction of glucose metabolism are often
comorbid with depression. The current study investigated whether a hypoglycemic state …

EXPLORING THE RELATIONSHIP BETWEEN HOPELESSNESS AND DISABILITY IN ELDERLY INDIVIDUALS WITH DIABETES.

Ş AYDİN, G GÖKÇAY - Turkish Journal of Geriatrics/Türk …, 2024 - search.ebscohost.com
Introduction: This study aimed to investigate the association between hopelessness and
disability in elderly individuals with diabetes. Materials and Method: The study involved 500 …

Effects of Interacting Stressors on Mood: Modulation by Ketamine

B Melanson - 2021 - atrium.lib.uoguelph.ca
Introduction. There is evidence in support of a link between metabolic and mood disorders.
Impaired glucose metabolism may play a role in the development of core depressive …

Role of Impaired Glucose Metabolism in Affective and Psychomotor Functions

T Horman - 2021 - atrium.lib.uoguelph.ca
It is becoming widely accepted that psychological dysfunctions that play a role in mental
health and psychiatric conditions are influenced by physiological functions in the body, such …

The Effect of Stressor Controllability on Social Hedonic Preference in Laboratory Rats

S Daniels - 2020 - atrium.lib.uoguelph.ca
Introduction. Major Depressive Disorder (MDD) is a devastating mood disorder
characterized by social anhedonic deficits. Stress and MDD are inextricably linked, however …