Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond

RW Bastos, L Rossato, GH Goldman… - PLoS Pathogens, 2021 - journals.plos.org
Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …

Molecular mechanisms governing antifungal drug resistance

Y Lee, N Robbins, LE Cowen - npj Antimicrobials and Resistance, 2023 - nature.com
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

NM Revie, KR Iyer, ME Maxson, J Zhang, S Yan… - Nature …, 2022 - nature.com
Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-
deficient susceptible populations and the emergence of antifungal drug resistance, there is …

A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

TF Dos Reis, PA De Castro, RW Bastos… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

New antifungal strategies: drug combination and co-delivery

P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

M Zhou, L Liu, Z Cong, W Jiang, X Xiao, J Xie… - Nature …, 2024 - nature.com
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting
compounds, which have multiple targets on a single pathogen, offer an effective approach to …

Peptide-Mimicking Poly (2-oxazoline) s Possessing Potent Antifungal Activity and BBB Penetrating Property to Treat Invasive Infections and Meningitis

W Jiang, M Zhou, S Chen, J Xie, M Chen… - Journal of the …, 2023 - ACS Publications
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …

Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence

RP Baker, A Casadevall - Nature communications, 2023 - nature.com
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation

BN Nelson, CS Daugherty, RR Sharp… - Frontiers in …, 2022 - frontiersin.org
Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …