Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond
RW Bastos, L Rossato, GH Goldman… - PLoS Pathogens, 2021 - journals.plos.org
Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …
Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-
deficient susceptible populations and the emergence of antifungal drug resistance, there is …
deficient susceptible populations and the emergence of antifungal drug resistance, there is …
A One Health approach to overcoming fungal disease and antifungal resistance
M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …
environmental health, endangering both human and livestock populations and creating …
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
TF Dos Reis, PA De Castro, RW Bastos… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …
New antifungal strategies: drug combination and co-delivery
P Zhu, Y Li, T Guo, S Liu, RJ Tancer, C Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …
resistance constitute a significant menace to human health. Antifungal drug combinations …
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting
compounds, which have multiple targets on a single pathogen, offer an effective approach to …
compounds, which have multiple targets on a single pathogen, offer an effective approach to …
Peptide-Mimicking Poly (2-oxazoline) s Possessing Potent Antifungal Activity and BBB Penetrating Property to Treat Invasive Infections and Meningitis
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …
available antifungal drugs and frequently associated side effects and quick emergence of …
Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence
RP Baker, A Casadevall - Nature communications, 2023 - nature.com
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …
Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation
BN Nelson, CS Daugherty, RR Sharp… - Frontiers in …, 2022 - frontiersin.org
Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …