Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal
diseases, generally characterized by meningitis. There is a limited and not very effective …

The rapid emergence of multidrug resistant microorganisms has become one of the most
critical threats to public health. A decrease in the effectiveness of available antibiotics has …

Cryptococcus neoformans is an important opportunistic human fungal pathogen that causes
cryptococcosis in immunocompromised patients. However, the number of drugs for the …

ABSTRACT The casein kinase 2 (CK2) complex has garnered extensive attention over the
past decades as a potential therapeutic target for diverse human diseases, including cancer …

Background. Cryptococcosis is one of the most common fungal infections in
immunocompromised patients, which is caused by Cryptococcus neoformans. However …

In our continuing efforts to discover novel triazoles with improved antifungal activity in vitro
and in vivo, a series of 41 novel compounds containing 1, 2, 3-triazole side chains were …

Staphylococcus aureus, a prominent pathogen, is frequently encountered in clinical and
food-processing settings. Given its ability to develop antimicrobial resistance, effective …

In pursuit of developing novel azole antifungals with potent activity and high selectivity, a
series of (2 R, 3 S)-3-(substituted-1 H-pyrazol-3-yl)-2-(2, 4-difluorophenyl)-1-(1 H-tetrazol-1 …

The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

When method-dependent categorical endpoints are available, namely either BPs or ECVs,
MICs could aid in selecting the best treatment agent (s). BPs can categorize an isolate as …