[HTML][HTML] Gut microbiota associated with cryptococcal meningitis and dysbiosis caused by anti-fungal treatment
H Li, L Zhang, K Zhang, Y Huang, Y Liu, X Lu… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota is a dynamic and highly diverse microbial ecosystem that affects many
aspects of the host's physiology. An improved understanding of the gut microbiota could …
aspects of the host's physiology. An improved understanding of the gut microbiota could …
[HTML][HTML] Alternative Oxidase–Aid or obstacle to combat the rise of fungal pathogens?
ESM Edrich, L Duvenage, CW Gourlay - Biochimica et Biophysica Acta …, 2024 - Elsevier
Fungal pathogens present a growing threat to both humans and global health security alike.
Increasing evidence of antifungal resistance in fungal populations that infect both humans …
Increasing evidence of antifungal resistance in fungal populations that infect both humans …
Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies
In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …
[HTML][HTML] Antifungals: from pharmacokinetics to clinical practice
The use of antifungal drugs started in the 1950s with polyenes nystatin, natamycin and
amphotericin B-deoxycholate (AmB). Until the present day, AmB has been considered to be …
amphotericin B-deoxycholate (AmB). Until the present day, AmB has been considered to be …
Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase
Y Wang, F Xu, CB Nichols, Y Shi… - Journal of medicinal …, 2022 - ACS Publications
Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …
[HTML][HTML] Current status of antihistamine drugs repurposing for infectious diseases
BL Travi - Medicine in Drug Discovery, 2022 - Elsevier
Objectives The principal objectives of this review were to gather information on the potential
role of antihistamines as anti-infective agents and to identify the gaps in research that have …
role of antihistamines as anti-infective agents and to identify the gaps in research that have …
[HTML][HTML] Assessing the In Vitro Potential of Glatiramer Acetate (Copaxone®) as a Chemotherapeutic Candidate for the Treatment of Cryptococcus neoformans …
V Alves, PH Martins, B Miranda, IB de Andrade… - Journal of Fungi, 2023 - mdpi.com
Cryptococcosis is a systemic mycosis affecting immunosuppressed individuals, caused by
various Cryptococcus species. The current treatment utilizes a combination of antifungal …
various Cryptococcus species. The current treatment utilizes a combination of antifungal …
[HTML][HTML] An Alternative Diagnostic Method for C. neoformans: Preliminary Results of Deep-Learning Based Detection Model
Cryptococcus neoformans is an opportunistic fungal pathogen with significant medical
importance, especially in immunosuppressed patients. It is the causative agent of …
importance, especially in immunosuppressed patients. It is the causative agent of …
Interdisciplinary approaches for the discovery of novel antifungals
Pathogenic fungi are an increasing public health concern. The emergence of antifungal
resistance coupled with the scarce antifungal arsenal highlights the need for novel …
resistance coupled with the scarce antifungal arsenal highlights the need for novel …
Nanomaterial-based therapeutics for enhanced antifungal therapy
F Liu, Y Chen, Y Huang, Q Jin, J Ji - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
The application of nanotechnology in antifungal therapy is gaining increasing attention.
Current antifungal drugs have significant limitations, such as severe side effects, low …
Current antifungal drugs have significant limitations, such as severe side effects, low …