[HTML][HTML] Gut microbiota associated with cryptococcal meningitis and dysbiosis caused by anti-fungal treatment

H Li, L Zhang, K Zhang, Y Huang, Y Liu, X Lu… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota is a dynamic and highly diverse microbial ecosystem that affects many
aspects of the host's physiology. An improved understanding of the gut microbiota could …

[HTML][HTML] Alternative Oxidase–Aid or obstacle to combat the rise of fungal pathogens?

ESM Edrich, L Duvenage, CW Gourlay - Biochimica et Biophysica Acta …, 2024 - Elsevier
Fungal pathogens present a growing threat to both humans and global health security alike.
Increasing evidence of antifungal resistance in fungal populations that infect both humans …

Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies

AK Mishra, RP Thakare, BG Santani, SM Yabaji… - Biochimie, 2023 - Elsevier
In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …

[HTML][HTML] Antifungals: from pharmacokinetics to clinical practice

A Carmo, M Rocha, P Pereirinha, R Tomé, E Costa - Antibiotics, 2023 - mdpi.com
The use of antifungal drugs started in the 1950s with polyenes nystatin, natamycin and
amphotericin B-deoxycholate (AmB). Until the present day, AmB has been considered to be …

Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase

Y Wang, F Xu, CB Nichols, Y Shi… - Journal of medicinal …, 2022 - ACS Publications
Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …

[HTML][HTML] Current status of antihistamine drugs repurposing for infectious diseases

BL Travi - Medicine in Drug Discovery, 2022 - Elsevier
Objectives The principal objectives of this review were to gather information on the potential
role of antihistamines as anti-infective agents and to identify the gaps in research that have …

[HTML][HTML] Assessing the In Vitro Potential of Glatiramer Acetate (Copaxone®) as a Chemotherapeutic Candidate for the Treatment of Cryptococcus neoformans …

V Alves, PH Martins, B Miranda, IB de Andrade… - Journal of Fungi, 2023 - mdpi.com
Cryptococcosis is a systemic mycosis affecting immunosuppressed individuals, caused by
various Cryptococcus species. The current treatment utilizes a combination of antifungal …

[HTML][HTML] An Alternative Diagnostic Method for C. neoformans: Preliminary Results of Deep-Learning Based Detection Model

A Seyer Cagatan, M Taiwo Mustapha, C Bagkur… - Diagnostics, 2022 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen with significant medical
importance, especially in immunosuppressed patients. It is the causative agent of …

Interdisciplinary approaches for the discovery of novel antifungals

B Yiu, N Robbins, LE Cowen - Trends in Molecular Medicine, 2024 - cell.com
Pathogenic fungi are an increasing public health concern. The emergence of antifungal
resistance coupled with the scarce antifungal arsenal highlights the need for novel …

Nanomaterial-based therapeutics for enhanced antifungal therapy

F Liu, Y Chen, Y Huang, Q Jin, J Ji - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
The application of nanotechnology in antifungal therapy is gaining increasing attention.
Current antifungal drugs have significant limitations, such as severe side effects, low …