Marine sponges have been considered as a gold mine during the past 50 years, with
respect to the diversity of their secondary metabolites. The biological effects of new …

Marine actinobacteria have been considered as a gold mine with respect to great potential
regarding their secondary metabolites. Most of the researches have been conducted on …

Background Although the molecular basis of resistance to a number of common antimalarial
drugs is well known, a geographic description of the emergence and dispersal of resistance …

Background. Plasmodium falciparum malaria resistant to chloroquine and pyrimethamine
originated in limited foci and migrated to Africa. It remains unresolved whether P. falciparum …

Sulfadoxine is predominantly used in combination with pyrimethamine, commonly known as
Fansidar, for the treatment of Plasmodium falciparum. This combination is usually less …

The combination of sulfadoxine-pyrimethamine (SP) is used as a second line of therapy for
the treatment of uncomplicated chloroquine-resistant Plasmodium falciparum malaria …

Background. Malaria during pregnancy is associated with low birth weight and increased
perinatal mortality, especially among primigravidae. Despite increasing prevalence of …

This document was prepared for the Roll Back Malaria Department of the World Health
Organization by Pascal Ringwald with the collaboration of Laura Shallcross, who was …

Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is
recommended as an additional malaria control intervention in high transmission areas of …

Abstract The S108N, C59R, and N51I mutations in the Plasmodium falciparum gene that
encodes dihydrofolate reductase, dhfr, confer resistance to pyrimethamine and are common …