How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?

PM Preshaw, JJ Taylor - Journal of clinical periodontology, 2011 - Wiley Online Library
Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

LH Aleksijević, M Aleksijević, I Škrlec, M Šram, M Šram… - Pathogens, 2022 - mdpi.com
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral
cavity. It is an integral part of the oral microbiome, which includes more than 500 types of …

[PDF][PDF] Role of bacteria in health and disease of periodontal tissues

Z Feng, A Weinberg - Periodontology 2000, 2006 - academia.edu
The interaction between bacteria and eukaryotic cells is complex; active processes must
exist that allow us to live harmoniously with the bacteria which normally live on and within …

Pathogen‐induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell‐specific innate immune inflammatory pathways

C Hayashi, CV Gudino, FC Gibson Iii… - Molecular oral …, 2010 - Wiley Online Library
A hallmark of infection with the gram‐negative pathogen Porphyromonas gingivalis is the
induction of a chronic inflammatory response. P. gingivalis induces a local chronic …

Generation of inflammatory stimuli: how bacteria set up inflammatory responses in the gingiva

PN Madianos, YA Bobetsis… - Journal of clinical …, 2005 - Wiley Online Library
Objectives: The primary aetiologic factor of periodontal disease is the bacterial biofilm. Gram‐
positive and Gram‐negative bacteria possess a plethora of structural or secreted …

Links between atherosclerotic and periodontal disease

DA Chistiakov, AN Orekhov, YV Bobryshev - Experimental and molecular …, 2016 - Elsevier
Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the
modern community. Both pathologies are chronic inflammatory disorders, which are …

Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced …

E Burns, G Bachrach, L Shapira… - The Journal of …, 2006 - journals.aai.org
Periodontitis is a chronic inflammatory disease that leads to destruction of the attachment
apparatus of the teeth. The presence of particular oral bacteria and the host inflammatory …

The role of Toll‐like receptors in periodontitis

B Song, YL Zhang, LJ Chen, T Zhou, WK Huang… - Oral …, 2017 - Wiley Online Library
Periodontitis is a common infectious disease. Recent studies have indicated that the
progression of periodontitis may be regulated by interactions between host immunity and …

Toll-like receptor signaling and immune regulatory lymphocytes in periodontal disease

Y Gu, X Han - International journal of molecular sciences, 2020 - mdpi.com
Periodontitis is known to be initiated by periodontal microbiota derived from biofilm
formation. The microbial dysbiotic changes in the biofilm trigger the host immune and …

Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4

S Gariboldi, M Palazzo, L Zanobbio… - The Journal of …, 2008 - journals.aai.org
In sites of inflammation or tissue injury, hyaluronic acid (HA), ubiquitous in the extracellular
matrix, is broken down into low mw HA (LMW-HA) fragments that have been reported to …