Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

For more than half a century, metabolic perturbations have been explored in the failing
myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by …

Redox networks in the cell integrate signaling pathways that control metabolism, energetics,
cell survival, and death. The physiological second messengers that modulate these …

There is a marked variation in mortality risk associated with COVID-19 infection in the
general population. Low socioeconomic status and other social determinants have been …

IT has been estimated that the red cells of more than 200 million people are deficient in the
enzyme glucose-6-phosphate dehydrogenase (G6PD). This X-linked hereditary deficiency …

The nicotinamide adenine dinucleotide (NAD+/NADH) and nicotinamide adenine
dinucleotide phosphate (NADP+/NADPH) redox couples function as cofactors or/and …

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

Like most other types of cancer cells, leukaemia cells undergo metabolic reprogramming to
support rapid proliferation through enhancing biosynthetic processes. Pentose phosphate …

Based on available metabolomic studies, influenza infection affects a variety of cellular
metabolic pathways to ensure an optimal environment for its replication and production of …