Metabolic coordination of physiological and pathological cardiac remodeling

AA Gibb, BG Hill - Circulation research, 2018 - Am Heart Assoc
Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

[HTML][HTML] Glucose transporters in cardiac metabolism and hypertrophy

D Shao, R Tian - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Metabolic origins of heart failure

AR Wende, MK Brahma, GR McGinnis… - Basic to Translational …, 2017 - jacc.org
For more than half a century, metabolic perturbations have been explored in the failing
myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by …

[HTML][HTML] Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics

AL Levonen, BG Hill, E Kansanen, J Zhang… - Free Radical Biology …, 2014 - Elsevier
Redox networks in the cell integrate signaling pathways that control metabolism, energetics,
cell survival, and death. The physiological second messengers that modulate these …

The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19

SK Jain, R Parsanathan, SN Levine, JA Bocchini… - Free Radical Biology …, 2020 - Elsevier
There is a marked variation in mortality risk associated with COVID-19 infection in the
general population. Low socioeconomic status and other social determinants have been …

Glucose-6-phosphate dehydrogenase deficiency

E Beutler - New England journal of medicine, 1991 - Mass Medical Soc
IT has been estimated that the red cells of more than 200 million people are deficient in the
enzyme glucose-6-phosphate dehydrogenase (G6PD). This X-linked hereditary deficiency …

Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

N Koju, Z Qin, R Sheng - Acta Pharmacologica Sinica, 2022 - nature.com
The nicotinamide adenine dinucleotide (NAD+/NADH) and nicotinamide adenine
dinucleotide phosphate (NADP+/NADPH) redox couples function as cofactors or/and …

Muscle wasting and aging: experimental models, fatty infiltrations, and prevention

T Brioche, AF Pagano, G Py, A Chopard - Molecular Aspects of Medicine, 2016 - Elsevier
Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation

SN Xu, TS Wang, X Li, YP Wang - Scientific Reports, 2016 - nature.com
Like most other types of cancer cells, leukaemia cells undergo metabolic reprogramming to
support rapid proliferation through enhancing biosynthetic processes. Pentose phosphate …

Metabolic host response and therapeutic approaches to influenza infection

M Keshavarz, F Solaymani-Mohammadi… - Cellular & Molecular …, 2020 - Springer
Based on available metabolomic studies, influenza infection affects a variety of cellular
metabolic pathways to ensure an optimal environment for its replication and production of …