The role of B cells in atherosclerosis

AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Systemic lupus erythematosus and cardiovascular disease

J Frostegård - Journal of Internal Medicine, 2023 - Wiley Online Library
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

[HTML][HTML] Potential natural immunization against atherosclerosis in hibernating bears

SK Samal, O Fröbert, J Kindberg, P Stenvinkel… - Scientific Reports, 2021 - nature.com
Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney
insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or …

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Chronic inflammatory diseases include cardiovascular disease (CVD),
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …

[HTML][HTML] Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

J Frostegård - Metabolites, 2023 - mdpi.com
Atherosclerosis and its main consequence, cardiovascular disease (CVD) are nowadays
regarded as chronic inflammatory disease conditions, and CVD is the main cause of death …

[HTML][HTML] Antibodies against phosphorylcholine among 60-year-olds: Clinical role and simulated interactions

SK Samal, PK Panda, M Vikström, K Leander… - Frontiers in …, 2022 - frontiersin.org
Aims Antibodies against phosphorylcholine (anti-PC) are implicated as protection markers in
atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory conditions …

[PDF][PDF] Immunoglobulin G1 antibodies against phosphorylcholine are associated with protection in systemic lupus erythematosus and atherosclerosis: Potential …

D Thiagarajan, R Fiskesund, A Frostegård… - ACR open …, 2020 - Wiley Online Library
Objective Immunoglobulin M antibodies against phosphorylcholine (anti‐PC s) may be
protective in atherosclerosis, cardiovascular disease (CVD), and systemic lupus …

Different subclasses and isotypes of antibodies against phosphorylcholine in haemodialysis patients: association with mortality

SK Samal, AR Qureshi, M Rahman… - Clinical & …, 2020 - academic.oup.com
The risk of premature death is high among patients on haemodialysis (HD patients). We
previously determined that immunoglobulin (Ig) M antibodies against phosphorylcholine …

Antibodies against phosphorylcholine among New Guineans compared to Swedes: an aspect of the hygiene/missing old friends hypothesis

J Frostegård, WJ Tao, L Råstam… - Immunological …, 2017 - Taylor & Francis
Background: We here study antibodies against phosphorylcholine (anti-PC) which we
reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and …

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

M Ståhle, JMU Silvola, S Hellberg, M de Vries… - Basic to Translational …, 2020 - jacc.org
This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1
antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow …