Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the
pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD …

OBJECTIVE: Uric acid (UA) levels are frequently increased in patients with heart failure (HF),
and may be an indicator of a poor prognosis and an innovative target for treatment. We …

Reactive oxygen species (ROS) are generated by several different cellular sources, and
their accumulation within the myocardium is widely considered to cause harmful oxidative …

The clinical efficacy of exercise training in individuals with heart failure is well established,
but the mechanism underlying such efficacy has remained unclear. An imbalance between …

The purine analog xanthine oxidase (XO) inhibitors (XOIs), allopurinol and oxypurinol, have
been reported to protect against heart failure secondary to myocardial infarction or rapid …

BACKGROUND: Previous studies have not extensively examined the association of
hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine …

The clinical use of doxorubicin is associated with dose limiting cardiotoxicity. This is a
manifestation of free radical production triggered by doxorubicin. Therefore, we evaluated …

Early life environmental exposure to xenobiotics could represent a critical period for the
onset of permanent alterations in the structure and function of different organs …

Rationale Obstructive sleep apnea is associated with left ventricular (LV) dysfunction,
oxidant stress, and chronic intermittent hypoxia (CIH). Allopurinol (ALLO) is a xanthine …