The problem of resistance to therapy in cancer is multifaceted. Here we take a reductionist
approach to define and separate the key determinants of drug resistance, which include …

The identification of molecular targets and the growing knowledge of their cellular functions
have led to the development of small molecule inhibitors as a major therapeutic class for …

In this report, the authors provide comprehensive and up‐to‐date US data on disparities in
cancer occurrence, major risk factors, and access to and utilization of preventive measures …

Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …

Abstract The AACR Project GENIE is an international data-sharing consortium focused on
generating an evidence base for precision cancer medicine by integrating clinical-grade …

Predicting the clinical response to chemotherapeutic or targeted treatment in patients with
locally advanced or metastatic lung cancer requires an accurate and affordable tool. Tumor …

Background In order to facilitate implementation of precision medicine in clinical
management of cancer, there is a need to harmonise and standardise the reporting and …

Early successes in identifying and targeting individual oncogenic drivers, together with the
increasing feasibility of sequencing tumor genomes, have brought forth the promise of …

FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

Importance To date, the benefit of genome-driven cancer therapy has not been quantified.
Objective We sought to estimate the annual percentage of patients in the United States with …