Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”,“the immune proteome” and “local antibiotic therapy”

EA Masters, RP Trombetta, KL de Mesy Bentley… - Bone research, 2019 - nature.com
Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Y Qing, L Cheng, R Li, G Liu, Y Zhang… - International journal …, 2018 - Taylor & Francis
Infection, as a common postoperative complication of orthopedic surgery, is the main reason
leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising …

Current applications of nanoparticles in infectious diseases

H Zazo, CI Colino, JM Lanao - Journal of Controlled Release, 2016 - Elsevier
For decades infections have been treated easily with drugs. However, in the 21st century,
they may become lethal again owing to the development of antimicrobial resistance …

Biomaterials against bone infection

M Vallet‐Regí, D Lozano, B González… - Advanced …, 2020 - Wiley Online Library
Chronic bone infection is considered as one of the most problematic biofilm‐related
infections. Its recurrent and resistant nature, high morbidity, prolonged hospitalization, and …

Silver nanoparticles and their orthopaedic applications

SA Brennan, CN Fhoghlú, BM Devitt… - The bone & joint …, 2015 - boneandjoint.org.uk
Implant-associated infection is a major source of morbidity in orthopaedic surgery. There has
been extensive research into the development of materials that prevent biofilm formation …

PMMA-based bone cements and the problem of joint arthroplasty infections: status and new perspectives

A Bistolfi, R Ferracini, C Albanese, E Vernè, M Miola - Materials, 2019 - mdpi.com
Polymethyl methacrylate (PMMA)-based bone cement is a biomaterial that has been used
over the last 50 years to stabilize hip and knee implants or as a bone filler. Although PMMA …

3D-printed bioceramic scaffolds with antibacterial and osteogenic activity

Y Zhang, D Zhai, M Xu, Q Yao, H Zhu, J Chang… - Biofabrication, 2017 - iopscience.iop.org
Bacterial infection poses a significant risk with the wide application of bone graft materials.
Designing bone grafts with good antibacterial performance and excellent bone-forming …

Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles

J Slane, J Vivanco, W Rose, HL Ploeg… - Materials Science and …, 2015 - Elsevier
Prosthetic joint infection is one of the most serious complications that can lead to failure of a
total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially …

Antimicrobial polymers in the nano-world

M Álvarez-Paino, A Muñoz-Bonilla… - Nanomaterials, 2017 - mdpi.com
Infections are one of the main concerns of our era due to antibiotic-resistant infections and
the increasing costs in the health-care sector. Within this context, antimicrobial polymers …

Infection resistant surface coatings by polymer brushes: strategies to construct and applications

S Dhingra, S Sharma, S Saha - ACS Applied Bio Materials, 2022 - ACS Publications
Bacteria-assisted infections on biomaterials used inside a body as an implant/device are
one of the major threats to human health. Microbial-resistant coatings on biomaterials can …