The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …

VEGF is a secreted growth factor that mediates its biological effects by binding to two
transmembrane tyrosine kinase receptors, VEGFR-1 and VEGFR-2. The VEGF/receptor …

Tumor growth is dependent in part on “neoangiogenesis.” Functional involvement of bone
marrow (BM)-derived cells in this process has been demonstrated. However, it remains …

Cellular and gene therapy are obvious approaches to correct rare genetic disorders and, in
the future, degenerative conditions. Both methods rely on the ability to identify and …

Direct clonal analysis of tissue and organ maturation in vivo is a critical step in the
interpretation of in vitro cell precursor-progeny relationships. We have developed a method …

During early embryogenesis, blood vessels and hematopoietic cells arise from a common
precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor …

Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of
the mature elements of the blood and immune system throughout the lifetime of an …

Considerable effort has been made in recent years in understanding the mechanisms that
govern stem cell generation, proliferation, self-renewal, commitment and lately plasticity. In …

The Lmo2 transcription factor, a T-cell oncoprotein, is required for both hematopoiesis and
angiogenesis. To investigate the fate of lmo2-expressing cells and the transcriptional …

Platelet-derived growth factor BB (PDGF-BB) has been assigned a critical role in vascular
stability by promoting the recruitment of PDGF receptor-β–expressing perivascular cells …