Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …

Myhre syndrome, a connective tissue disorder characterized by deafness, restricted joint
movement, compact body habitus, and distinctive craniofacial and skeletal features, is …

Background Myhre syndrome is a rare multisystem genetic disorder that is caused by de
novo heterozygous gain‐of‐function variants in SMAD4. Patients with Myhre syndrome …

Myhre syndrome is a multisystem connective tissue disorder involving the skin and the
cardiovascular, respiratory, gastrointestinal, and musculoskeletal systems. Affected …

Over 30 years ago Myhre and colleagues described a syndrome characterized by deafness,
dysmorphic facial features, thick or stiff skin, restrictive joint movement, skeletal anomalies …

Myhre syndrome is a multisystem connective tissue disorder involving the skin and the
cardiovascular, respiratory, gastrointestinal, and musculoskeletal systems. Affected …

Background: Myhre syndrome (MS) is a very rare connective tissue disorder characterized
by facial dysmorphism, thickened skin, muscular pseudohypertrophy and joint limitation …

Abstract Syndecan-3 (Sdc3), a transmembrane heparan sulphate proteoglycan receptor, is
highly expressed in periosteal osteoblasts during skeletal development, but its role in the …