Airway nerves represent a mechanistically and therapeutically important aspect that requires
better highlighting in the context of diseases such as asthma. Altered structure and function …

Asthma is a chronic inflammation of lower airway disease, characterized by bronchial
hyperresponsiveness. Type I hypersensitivity underlies all atopic diseases including allergic …

Background Data on the neuromodulatory effects of brain‐derived neurotrophic factor
(BDNF) in the gastrointestinal tract were recently reported, but there are still no data on the …

Senescent cells can drive age-related tissue dysfunction partially via a senescence-
associated secretory phenotype (SASP) involving proinflammatory and profibrotic factors …

Abstract Maxing Ganshi Decoction (MXGSD) is used widely for asthma over thousands of
years, but its underlying pharmacological mechanisms remain unclear. In this study …

Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in
close proximity to both stromal and immune cell populations. Together with a growing …

Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the
central nervous system. Numerous studies suggest that BDNF has extensive roles by …

Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …

Lung function declines as people age and their lungs become stiffer. With an increasing
elderly population, understanding mechanisms that contribute to these structural and …

Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a
hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of …