Benzodiazepines in the management of seizures and status epilepticus: a review of routes of delivery, pharmacokinetics, efficacy, and tolerability

R Kienitz, L Kay, I Beuchat, S Gelhard… - CNS drugs, 2022 - Springer
Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

Guidelines for the evaluation and management of status epilepticus

GM Brophy, R Bell, J Claassen, B Alldredge, TP Bleck… - Neurocritical care, 2012 - Springer
Status epilepticus (SE) treatment strategies vary substantially from one institution to another
due to the lack of data to support one treatment over another. To provide guidance for the …

Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society

T Glauser, S Shinnar, D Gloss, B Alldredge… - Epilepsy …, 2016 - journals.sagepub.com
CONTEXT: The optimal pharmacologic treatment for early convulsive status epilepticus is
unclear. OBJECTIVE: To analyze efficacy, tolerability and safety data for anticonvulsant …

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children

A McTague, T Martland… - Cochrane Database of …, 2018 - cochranelibrary.com
Background Tonic‐clonic convulsions and convulsive status epilepticus (currently defined
as a tonic‐clonic convulsion lasting at least 30 minutes) are medical emergencies and …

Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta‐analysis

J McMullan, C Sasson, A Pancioli… - Academic emergency …, 2010 - Wiley Online Library
Background: Rapid treatment of status epilepticus (SE) is associated with better outcomes.
Diazepam and midazolam are commonly used, but the optimal agent and administration …

Treatment of refractory status epilepticus: literature review and a proposed protocol

NS Abend, DJ Dlugos - Pediatric neurology, 2008 - Elsevier
Refractory status epilepticus describes continuing seizures despite adequate initial
pharmacologic treatment. This situation is common in children, but few data are available to …

Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial

A Mpimbaza, G Ndeezi, S Staedke, PJ Rosenthal… - …, 2008 - publications.aap.org
OBJECTIVE. Our goal was to compare the efficacy and safety of buccal midazolam with
rectal diazepam in the treatment of prolonged seizures in Ugandan children. METHODS …

Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: a systematic review with meta-analysis

F Brigo, R Nardone, F Tezzon, E Trinka - Epilepsy & Behavior, 2015 - Elsevier
Background Prompt treatment of status epilepticus (SE) is associated with better outcomes.
Rectal diazepam (DZP) and nonintravenous (non-IV) midazolam (MDZ) are often used in the …

Benzodiazepine use in seizure emergencies: a systematic review

SR Haut, S Seinfeld, J Pellock - Epilepsy & Behavior, 2016 - Elsevier
Purpose The aim of this review was to systematically examine safety and efficacy outcomes,
as well as patient/caregiver satisfaction, from clinical studies in pediatric and adult patients …

Time is brain: acute control of repetitive seizures and status epilepticus using alternative routes of administration of benzodiazepines

S Almohaish, M Sandler, GM Brophy - Journal of Clinical Medicine, 2021 - mdpi.com
Time plays a major role in seizure evaluation and treatment. Acute repetitive seizures and
status epilepticus are medical emergencies that require immediate assessment and …