Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Aortic dissections and aortic aneurysms are fatal events characterized by structural changes
to the aortic wall. The maximum diameter criterion, typically used for aneurysm rupture risk …

Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled
by a ground matrix and embedded families of collagen fibres. Changes in the structural …

The past two decades reveal a growing role of continuum biomechanics in understanding
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Background—Stiffening of the aortic wall is a phenomenon consistently observed in age and
in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely …

A deeper understanding to predict fracture in soft biological tissues is of crucial importance
to better guide and improve medical monitoring, planning of surgical interventions and risk …

This study uses a recently developed phase-field approach to model fracture of arterial walls
with an emphasis on aortic tissues. We start by deriving the regularized crack surface to …

Abdominal aortic aneurysm (AAA) is the dilatation of the aorta beyond 50% of the normal
vessel diameter. It is reported that 4–8% of men and 0.5–1% of women above 50 years of …

Vulnerable and stable atherosclerotic plaques are heterogeneous living materials with
peculiar mechanical behaviors depending on geometry, composition, loading and boundary …