Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance
of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated …

Insulin clearance has recently been highlighted as a fundamental aspect of glucose
metabolism, as it has been hypothesized that its impairment could be related to an …

Abstract Background African Americans (AAs) are at a higher risk for developing type 2
diabetes compared with non-Hispanic whites (NHWs). The causal role of β-cell glucose …

Aging is characterized by a progressive loss of physiological function leading to increase in
the vulnerability to death. This deterioration process occurs in all living organisms and is the …

Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic
syndrome, which are important pathogenic factors in the development of type 2 diabetes. In …

Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty
acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in …

Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …

Obesity is a worldwide life-threatening metabolic disorder, associated with various chronic
diseases, including male infertility. Obesity was induced by high fat diet (HFD), and testis …