ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

The maintenance of cellular cholesterol homeostasis is essential for normal cell function and
viability. Excessive cholesterol accumulation is detrimental to cells and serves as the …

ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of
phospholipids and cholesterol to the extracellular acceptor apolipoprotein AI (apoA-I) for …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …

Plant cells coordinately regulate the expression of nuclear and plastid genes that encode
components of the photosynthetic apparatus. Nuclear genes that regulate chloroplast …

ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette
transporters that share extensive sequence and structural similarity. Mutations in ABCA1 …

ABCA1 functions as a lipid transporter because it mediates the transfer of cellular
phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins …

The removal of excess free cholesterol from cells by HDL or its apolipoproteins is important
for maintaining cellular cholesterol homeostasis. This process is most likely compromised in …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …