Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder.
During the past two decades in excess of 100 X-chromosome ID genes have been …

We describe the results of a genome-wide analysis of human cells that suggests that most
protein-coding genes, including most genes thought to be transcriptionally inactive …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Cells employ elaborate mechanisms to introduce structural and chemical variation into
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …

Epigenetic chromatin marks restrict the ability of differentiated cells to change gene
expression programs in response to environmental cues and to transdifferentiate. Polycomb …

Translocations involving the mixed lineage leukemia (MLL) gene result in human acute
leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is …

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …