[HTML][HTML] Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia
Here we report a comprehensive characterization of our recently developed inhibitor MM-
401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically …
401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically …
ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
The commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX,
DAXX, and MEN1. We genotyped 64 PanNETs and found 58% carry ATRX, DAXX, and …
DAXX, and MEN1. We genotyped 64 PanNETs and found 58% carry ATRX, DAXX, and …
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Abstract Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with
transcription activation. A common feature of several H3K4 methyltransferase complexes is …
transcription activation. A common feature of several H3K4 methyltransferase complexes is …
hDOT1L links histone methylation to leukemogenesis
Epigenetic modifications play an important role in human cancer. One such modification,
histone methylation, contributes to human cancer through deregulation of cancer-relevant …
histone methylation, contributes to human cancer through deregulation of cancer-relevant …
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene
MC Lemos, RV Thakker - Human mutation, 2008 - Wiley Online Library
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
A Yokoyama, TCP Somervaille, KS Smith… - Cell, 2005 - cell.com
Summary The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …
MEN4 and CDKN1B mutations: the latest of the MEN syndromes
R Alrezk, F Hannah-Shmouni… - Endocrine-related …, 2017 - erc.bioscientifica.com
Multiple endocrine neoplasia (MEN) refers to a group of autosomal dominant disorders with
generally high penetrance that lead to the development of a wide spectrum of endocrine and …
generally high penetrance that lead to the development of a wide spectrum of endocrine and …
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
Summary Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional
activation in a variety of eukaryotic species. Here we show that a common component of …
activation in a variety of eukaryotic species. Here we show that a common component of …
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
JW Edmunds, LC Mahadevan, AL Clayton - The EMBO journal, 2008 - embopress.org
Understanding the function of histone modifications across inducible genes in mammalian
cells requires quantitative, comparative analysis of their fate during gene activation and …
cells requires quantitative, comparative analysis of their fate during gene activation and …
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies
Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …
release biologically active hormones that cause distinct syndromes and provide important …