Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

Menin displays the unique ability to either promote oncogenic function in the hematopoietic
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …

A stable complex containing MLL1 and MOF has been immunoaffinity purified from a human
cell line that stably expresses an epitope-tagged WDR5 subunit. Stable interactions …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …

PTIP, a protein with tandem BRCT domains, has been implicated in DNA damage response.
However, its normal cellular functions remain unclear. Here we show that while ectopically …

Chromatin reorganization is governed by multiple post-translational modifications of
chromosomal proteins and DNA,. These histone modifications are reversible, dynamic …

MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human
leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic …

In yeast, histone H2B monoubiquitination is a cotranscriptional event regulating histone H3
methylation at lysines 4 and 79. However, mammalian H2B monoubiquitination remains …

Eukaryotic genomes are organized into active (euchromatic) and inactive (heterochromatic)
chromatin domains. Post-translational modifications of histones (or 'marks') are key in …