Chromosomal surfaces are ornamented with a variety of post-translational modifications of
histones, which are required for the regulation of many of the DNA-templated processes …

A common landmark of activated genes is the presence of trimethylation on lysine 4 of
histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is …

Transcriptional regulation at the level of elongation is vital for the control of gene expression
and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila …

Covalent modification of histones on chromatin is a dynamic mechanism by which various
nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented …

COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4
(H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including …

Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Proliferation of pancreatic islet β cells is an important mechanism for self-renewal and for
adaptive islet expansion. Increased expression of the Ink4a/Arf locus, which encodes the …

Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine
neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is …

Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many
of these proteins regulate specific genes by targeting upstream promoter regions, whereas a …

Kabuki syndrome (KS) is a rare multiple congenital anomaly syndrome characterized by
distinctive facial features, global developmental delay, intellectual disability and …