Mutations in the MEN1 gene are associated with the multiple endocrine neoplasia syndrome
type 1 (MEN1), which is characterized by parathyroid hyperplasia and tumors of the pituitary …

AF4 and ENL family proteins are frequently fused with MLL, and they comprise a higher
order complex (designated AEP) containing the P-TEFb transcription elongation factor …

Satellite cells purified from adult skeletal muscle can participate extensively in muscle
regeneration and can also re-populate the satellite cell pool, suggesting that they have …

Resistance to androgen deprivation therapies and increased androgen receptor (AR)
activity are major drivers of castration-resistant prostate cancer (CRPC). Although prior work …

Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional
regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) …

In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a
posttranslational modification associated with actively transcribed genes. There is only one …

ALR (MLL2) is a member of the human MLL family, which belongs to a larger SET1 family of
histone methyltransferases. We found that ALR is present within a stable multiprotein …

During pregnancy, maternal pancreatic islets grow to match dynamic physiological
demands, but the mechanisms regulating adaptive islet growth in this setting are poorly …

Menin, the product of the Men1 gene mutated in familial multiple endocrine neoplasia type 1
(MEN1), regulates transcription in differentiated cells. Menin associates with and modulates …

Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …