Summary The Mixed Lineage Leukemia (MLL) gene is essential for embryonic
hematopoietic stem cell (HSC) development, but its role during adult hematopoiesis is …

MLL complexes are homologs of yeast COMPASS capable of methylating histone H3 Lys4
(H3K4). ASH2L, RbBP5 and WDR5 are conserved subunits of MLL complexes with …

The arginine methyltransferase PRMT6 (protein arginine methyltransferase 6) has been
shown recently to regulate DNA repair and gene expression. As arginine methylation of …

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper
regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding …

Rearrangements of the MLL gene, which is located at chromosome 11q23, are associated
with aggressive acute leukemias in both children and adults. MLL regulates Hox gene …

In all organisms, cell proliferation is orchestrated by coordinated patterns of gene
expression. Transcription results from the activity of the RNA polymerase machinery and …

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at
bivalent promoters is essential for normal development and frequently corrupted in cancer …

CpG-binding protein (CXXC finger protein 1 (CFP1)) binds to DNA containing unmethylated
CpG motifs and is required for mammalian embryogenesis, normal cytosine methylation …

Histone 3 lysine 4 (H3K4) methylation is a universal epigenetic mark. In mammals, there are
six H3K4 methyltransferases related to yeast Set1 and fly Trithorax, including two orthologs …

The Set1-containing complex COMPASS, which is the yeast homolog of the human MLL
complex, is required for mono-, di-, and trimethylation of lysine 4 of histone H3. We have …