Organisms alter gene expression to adapt to changes in environmental conditions such as
temperature, nutrients, inflammatory signals, and stress (Gialitakis et al. in Mol Cell Biol 30 …

Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …

Transcription in eukaryotic genomes depends on enzymes that regulate the degree of
histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …

Abstract Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase
that participates in numerous signalling pathways involved in diverse physiological …

Epigenesis is the process whereby the daughters of a dividing cell retain a chromatin state
determined before cell division. The best-studied cases involve the inheritance of …

Posttranslational modifications of histones are coupled in the regulation of the cellular
processes involving chromatin, such as transcription, replication, repair, and genome …

Six multiple endocrine neoplasia (MEN) syndromes have received a level of attention that
might seem disproportionate to their low prevalence. The attention has been given because …

MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that
respond poorly to treatment, but how they recognize and stably bind to HoxA9 is not clearly …

We previously identified a mammalian Set1A complex analogous to the yeast
Set1/COMPASS histone H3-Lys4 methyltransferase complex (Lee, J.-H., and Skalnik, DG …