Multiple endocrine neoplasia type 1 (MEN1)
RV Thakker - Best practice & research Clinical endocrinology & …, 2010 - Elsevier
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal-dominant disorder
characterised by the occurrence of tumours of the parathyroids, pancreas and anterior …
characterised by the occurrence of tumours of the parathyroids, pancreas and anterior …
[HTML][HTML] Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory:
repressed genes that exhibit mitotically heritable changes in chromatin structure and …
repressed genes that exhibit mitotically heritable changes in chromatin structure and …
The parafibromin tumor suppressor protein is part of a human Paf1 complex
O Rozenblatt-Rosen, CM Hughes… - … and cellular biology, 2005 - Am Soc Microbiol
Parafibromin, the product of the HRPT2 (hyperparathyroidism-jaw tumor syndrome 2) tumor
suppressor gene, is the human homologue of yeast Cdc73, part of the yeast RNA …
suppressor gene, is the human homologue of yeast Cdc73, part of the yeast RNA …
[HTML][HTML] Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
[HTML][HTML] MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele
Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-
type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) …
type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) …
[HTML][HTML] Androgen receptor antagonists for prostate cancer therapy
C Helsen, T Van den Broeck, A Voet… - Endocrine-related …, 2014 - erc.bioscientifica.com
Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-
cells and can occur either as sporadic or as hereditary diseases in the context of familial …
cells and can occur either as sporadic or as hereditary diseases in the context of familial …
Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities
DRA Swarts, FCS Ramaekers, EJM Speel - Biochimica et Biophysica Acta …, 2012 - Elsevier
Pulmonary neuroendocrine tumors (NETs) are traditionally described as comprising a
spectrum of neoplasms, ranging from low grade typical carcinoids (TCs) via the intermediate …
spectrum of neoplasms, ranging from low grade typical carcinoids (TCs) via the intermediate …
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex
AJ Ruthenburg, W Wang, DM Graybosch, H Li… - Nature structural & …, 2006 - nature.com
WDR5 is a core component of SET1-family complexes that achieve transcriptional activation
via methylation of histone H3 on Nζ of Lys4 (H3K4). The role of WDR5 in the MLL1 complex …
via methylation of histone H3 on Nζ of Lys4 (H3K4). The role of WDR5 in the MLL1 complex …
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia
Acute myeloid leukemia (AML) remains difficult to treat and requires new therapeutic
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …
[HTML][HTML] MLL:: AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
MLL rearrangements produce fusion oncoproteins that drive leukemia development, but the
direct effects of MLL-fusion inactivation remain poorly defined. We designed models with …
direct effects of MLL-fusion inactivation remain poorly defined. We designed models with …