Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating
histones and non-histone proteins and regulating chromatin and gene-specific transcription …

The MLL family of histone methyltransferases maintains active chromatin domains by
methylating histone H3 on lysine 4 (H3K4). How MLL complexes recognize specific …

Much of the genome is transcribed into long noncoding RNAs (ncRNAs). Previous data
suggested that bithoraxoid (bxd) ncRNAs of the Drosophila bithorax complex (BX-C) prevent …

Recent data suggest an increase in the overall incidence of parathyroid disorders, with
primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is …

The WD40-repeat protein WDR5 is a conserved subunit of Trithorax (TRX) histone
methyltransferase complexes. WDR5 has been reported to selectively bind dimethylated …

Histone lysine methylation plays a fundamental role in chromatin organization and function.
This epigenetic mark is involved in many biological processes such as heterochromatin …

The mixed lineage leukemia protein-1 (MLL1) belongs to the SET1 family of histone H3
lysine 4 methyltransferases. Recent studies indicate that the catalytic subunits of SET1 …

MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific methyltransferase that is a
positive regulator of Hox expression. MLL rearrangements and amplification are common in …

Abstract The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation
partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined …

Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing.
Genomic analyses in Drosophila and mammals, however, have shown that it targets many …