A rapid epistatic mixed-model association analysis by linear retransformations of genomic estimated values
Motivation Epistasis provides a feasible way for probing potential genetic mechanism of
complex traits. However, time-consuming computation challenges successful detection of …
complex traits. However, time-consuming computation challenges successful detection of …
GASVeM: a new machine learning methodology for multi-SNP analysis of GWAS data based on genetic algorithms and support vector machines
F Díez Díaz, F Sánchez Lasheras, V Moreno… - Mathematics, 2021 - mdpi.com
Genome-wide association studies (GWAS) are observational studies of a large set of genetic
variants in an individual's sample in order to find if any of these variants are linked to a …
variants in an individual's sample in order to find if any of these variants are linked to a …
On the use of GBLUP and its extension for GWAS with additive and epistatic effects
Genomic best linear unbiased prediction (GBLUP) is the most widely used model for
genome-wide predictions. Interestingly, it is also possible to perform genome-wide …
genome-wide predictions. Interestingly, it is also possible to perform genome-wide …
Interpreting coronary artery disease GWAS results: a functional genomics approach assessing biological significance
Genome-wide association studies (GWAS) have implicated 58 loci in coronary artery
disease (CAD). However, the biological basis for these associations, the relevant genes …
disease (CAD). However, the biological basis for these associations, the relevant genes …
Evolutionary footprint of epistasis
G Pedruzzi, A Barlukova… - PLOS Computational …, 2018 - journals.plos.org
Variation of an inherited trait across a population cannot be explained by additive
contributions of relevant genes, due to epigenetic effects and biochemical interactions …
contributions of relevant genes, due to epigenetic effects and biochemical interactions …
An exploration of gene‐gene interactions and their effects on hypertension
Y Meng, S Groth, JR Quinn… - International journal of …, 2017 - Wiley Online Library
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated
to be around 20–60%. So far, the main proportion of this heritability has not been found by …
to be around 20–60%. So far, the main proportion of this heritability has not been found by …
Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan
Introduction The genetic association between depression and migraine has not been well
investigated in Asian populations. Furthermore, the genetic basis of depression and …
investigated in Asian populations. Furthermore, the genetic basis of depression and …
Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles
Background Alterations in gene expression are key events in disease etiology and risk. Poor
reproducibility in detecting differentially expressed genes across studies suggests individual …
reproducibility in detecting differentially expressed genes across studies suggests individual …
Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease
Objective Only a small fraction of coronary artery disease (CAD) heritability has been
explained by common variants identified to date. Interactions between genes of importance …
explained by common variants identified to date. Interactions between genes of importance …
Prioritizing tests of epistasis through hierarchical representation of genomic redundancies
T Cowman, M Koyutürk - Nucleic acids research, 2017 - academic.oup.com
Epistasis is defined as a statistical interaction between two or more genomic loci in terms of
their association with a phenotype of interest. Epistatic loci that are identified using data from …
their association with a phenotype of interest. Epistatic loci that are identified using data from …