Immunochip analyses of epistasis in rheumatoid arthritis confirm multiple interactions within MHC and suggest novel non-MHC epistatic signals
WH Wei, CY Loh, J Worthington, S Eyre - The Journal of rheumatology, 2016 - jrheum.org
Objective. Studying statistical gene-gene interactions (epistasis) has been limited by the
difficulties in performance, both statistically and computationally, in large enough sample …
difficulties in performance, both statistically and computationally, in large enough sample …
Genome‐wide association studies for epistatic genetic effects on fertility and reproduction traits in Holstein cattle
K Alves, LF Brito, M Sargolzaei… - Journal of Animal …, 2023 - Wiley Online Library
Non‐additive genetic effects are well known to play an important role in the phenotypic
expression of complex traits, such as fertility and reproduction. In this study, a genome scan …
expression of complex traits, such as fertility and reproduction. In this study, a genome scan …
Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy
Background Previous genome-wide association study (GWAS) identified two new leprosy
associated loci (1p31. 3 [rs3762318] and 6q24. 3 [rs2275606]). However, there were …
associated loci (1p31. 3 [rs3762318] and 6q24. 3 [rs2275606]). However, there were …
Heckerthoughts
D Heckerman - arXiv preprint arXiv:2302.05449, 2023 - arxiv.org
In 1987, Eric Horvitz, Greg Cooper, and I visited IJ Good at his university. We wanted to see
him was not because he worked with Alan Turing to help win WWII by decoding encrypted …
him was not because he worked with Alan Turing to help win WWII by decoding encrypted …
Linear mixed models for genome-wide association studies
C Lippert - 2013 - tobias-lib.ub.uni-tuebingen.de
Genome-wide association studies aim at uncovering genetic loci that regulate a phenotype
of interest by performing statistical tests for association between observed genetic variants …
of interest by performing statistical tests for association between observed genetic variants …
Transcriptome-Wide Gene-Gene Interaction Association Study Elucidates Pathways and Functional Enrichment of Complex Traits
It remains unknown to what extent gene-gene interactions contribute to complex traits. Here,
we introduce a new approach using predicted gene expression to perform exhaustive …
we introduce a new approach using predicted gene expression to perform exhaustive …
A model to investigate SNPs' interaction in GWAS studies
Genome-wide association studies (GWAS) are able to identify the role of individual SNPs in
influencing a phenotype. Nevertheless, such analysis is unable to explain the biological …
influencing a phenotype. Nevertheless, such analysis is unable to explain the biological …
Accelerating FaST-LMM for epistasis tests
We introduce an enhanced version of FaST-LMM that maintains the sensitivity of this
software when applied to identify epistasis interactions while delivering an acceleration …
software when applied to identify epistasis interactions while delivering an acceleration …
[PDF][PDF] Understanding epistatic interactions between genes targeted by non-coding regulatory elements in complex diseases
SNP1 rsID SNP1 position SNP2 rsID SNP2 position p-value rs11758807 chr6 36794573
36794574 rs6027482 chr20 58880251 58880252 5.73 E-06 rs9368963 chr6 36798005 …
36794574 rs6027482 chr20 58880251 58880252 5.73 E-06 rs9368963 chr6 36798005 …
Overcoming the" Feast or Famine" Effect: Improved Interaction Testing in GWAS
H Zhou - 2024 - knowledge.uchicago.edu
In genetic association analysis of complex traits, detection of interaction (either GxG or GxE)
can help to elucidate the genetic architecture and biological mechanisms underlying the …
can help to elucidate the genetic architecture and biological mechanisms underlying the …