Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

In this study, a two-photon ratiometric fluorescent probe NCEN has been designed and
developed for highly selective and sensitive sensing of human carboxylesterase 2 (hCE2) …

The binding interaction between a typical angiotensin-converting enzyme inhibitor (ACEI),
ramipril, and a transport protein, bovine serum albumin (BSA), was studied in vitro using UV …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …

Synthetic cannabimimetic agents are a large group of diverse compounds which act as
agonists at cannabinoid receptors. Since 2004, synthetic cannabinoids have been used …

Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …

Rational design of practical probes with excellent specificity and improved optical properties
for a particular enzyme is always a big challenge. Herein, a practical and highly specific …