Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic
knowledge and provides expedited solutions to complex challenges. Remarkable …

Advances in nanomedicine, coupled with novel methods of creating advanced materials at
the nanoscale, have opened new perspectives for the development of healthcare and …

Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of
drug development in the costly late stage, it has been widely recognized that drug ADMET …

The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …

Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been
associated with the development of a wide range of diseases and health problems in …

Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …

The economic and health burden caused by adverse drug reactions has increased
dramatically in the last few years. This is likely to be mediated by increasing polypharmacy …

Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

Background: In January 2020, the US FDA published two final guidelines, one entitled “In
vitro Drug Interaction Studies-Cytochrome P450 Enzyme-and Transporter-Mediated Drug …