Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

Disclaimer: These guidelines for adult and pediatric anticoagulation for extracorporeal
membrane oxygenation are intended for educational use to build the knowledge of …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background The resuscitation of severely injured bleeding patients has evolved into a multi-
modal strategy termed damage control resuscitation (DCR). This guideline evaluates …

This is the first UK national guideline to concentrate on acute lower gastrointestinal bleeding
(LGIB) and has been commissioned by the Clinical Services and Standards Committee of …

Patient blood management (PBM) is the timely application of evidence-informed medical
and surgical concepts designed to maintain haemoglobin concentration, optimise …

Background The use of tranexamic acid reduces mortality due to postpartum hemorrhage.
We investigated whether the prophylactic administration of tranexamic acid in addition to …

The story of the discovery of aspirin stretches back more than 3500 years to when bark from
the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire …

Background Effective treatment of trauma-induced coagulopathy is important; however, the
optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy …