Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance-A review
Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The
lack of reliable means of early cancer detection contributes to this disease's dismal …
lack of reliable means of early cancer detection contributes to this disease's dismal …
[HTML][HTML] Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents
M Hashemi, MSA Mirdamadi, Y Talebi… - Pharmacological …, 2023 - Elsevier
The field of non-coding RNA (ncRNA) has made significant progress in understanding the
pathogenesis of diseases and has broadened our knowledge towards their targeting …
pathogenesis of diseases and has broadened our knowledge towards their targeting …
[HTML][HTML] A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: complexity and simplicity in crosstalk
Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
[HTML][HTML] Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update
Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …
biology has expanded substantially. miRNAs are involved and described as master …
[HTML][HTML] Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment
Z Rong, J Xu, S Shi, Z Tan, Q Meng, J Hua, J Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …
[HTML][HTML] Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair
X Zhang, S Zheng, C Hu, G Li, H Lin, R Xia, Y Ye, R He… - Oncogene, 2022 - nature.com
The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an
abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are …
abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are …
Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches
A high number of cancer patients around the world rely on gemcitabine (GEM) for
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …
Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy
W Wang, W Liu, Q Chen, Y Yuan, P Wang - Seminars in Cancer Biology, 2022 - Elsevier
Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …
[HTML][HTML] LncRNA MALAT1 regulates METTL3-mediated PD-L1 expression and immune infiltrates in pancreatic cancer
Z Song, X Wang, F Chen, Q Chen, W Liu, X Yang… - Frontiers in …, 2022 - frontiersin.org
Pancreatic cancer is the fourth leading cause of cancer death in the United States. The main
methods of treating pancreatic cancer are surgery and chemotherapy, but the treatment …
methods of treating pancreatic cancer are surgery and chemotherapy, but the treatment …
[HTML][HTML] Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis
Y Chi, H Xin, Z Liu - Frontiers in Oncology, 2021 - frontiersin.org
Objective Pancreatic cancer is associated with poor prognosis and dismal survival rates.
This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by …
This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by …