Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus

MD Johansen, JL Herrmann, L Kremer - Nature Reviews Microbiology, 2020 - nature.com
Infections caused by non-tuberculous mycobacteria (NTM) are increasing globally and are
notoriously difficult to treat due to intrinsic resistance of these bacteria to many common …

[HTML][HTML] Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare

RC Lopeman, J Harrison, M Desai, JAG Cox - Microorganisms, 2019 - mdpi.com
Mycobacteria are a large family of over 100 species, most of which do not cause diseases in
humans. The majority of the mycobacterial species are referred to as nontuberculous …

Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection

DA Nicklas, EC Maggioncalda… - Antimicrobial agents …, 2022 - Am Soc Microbiol
The incidence of nontuberculous mycobacterial diseases in the United States is rising and
has surpassed that of tuberculosis. Most notable among the nontuberculous mycobacteria is …

[HTML][HTML] Mycobacterium abscessus: It's Complex

HFM Abdelaal, ED Chan, L Young, SL Baldwin… - Microorganisms, 2022 - mdpi.com
Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing
abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no …

Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease

V Dartois, T Dick - Nature Reviews Drug Discovery, 2024 - nature.com
Tuberculosis (TB) drug discovery and development has undergone nothing short of a
revolution over the past 20 years. Successful public–private partnerships and sustained …

Pipeline of anti‐Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities

A Egorova, M Jackson, V Gavrilyuk… - Medicinal research …, 2021 - Wiley Online Library
The Mycobacterium abscessus complex is a group of emerging pathogens that are difficult
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …

Nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex - disease burden, unmet needs, and advances in treatment developments

J van Ingen, M Obradovic, M Hassan… - Expert Review of …, 2021 - Taylor & Francis
Introduction Nontuberculous mycobacterial (NTM) lung disease (LD) is the most common
clinical manifestation of NTM infection and is a growing health concern. Up to 85% of NTM …

Treatment approaches to Mycobacterium abscessus pulmonary disease

MR Holt, T Baird - Clinics in Chest Medicine, 2023 - chestmed.theclinics.com
Mycobacterium abscessus complex is the most common cause of rapid-grower
nontuberculous mycobacterial pulmonary disease (NTM-PD) and a significant contributor to …

[HTML][HTML] Looking beyond typical treatments for atypical mycobacteria

CM Bento, MS Gomes, T Silva - Antibiotics, 2020 - mdpi.com
The genus Mycobacterium comprises not only the deadliest of bacterial pathogens,
Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and …

[HTML][HTML] International Society of Cardiovascular Infectious Diseases guidelines for the diagnosis, treatment and prevention of disseminated Mycobacterium chimaera …

B Hasse, MM Hannan, PM Keller, FP Maurer… - Journal of Hospital …, 2020 - Elsevier
Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary
bypass surgery is high and there is a growing need for a consensus-based expert opinion to …