Descriptions of epileptic seizures and epilepsy date back to antiquity, and research into
fundamental mechanisms of epilepsy in animal models, as well as patients, has been …

The causes of neurodegenerative diseases are complex with likely contributions from
genetic susceptibility and environmental exposures over an organism's lifetime. In this …

GABA ergic interneurons control the neural circuitry and network activity in the brain. The
advances in genetics have identified genes that control the development, maturation, and …

Several preclinical proof‐of‐concept studies have provided evidence for positive treatment
effects on epileptogenesis. However, none of these hypothetical treatments has advanced to …

The treatment of infantile spasms is challenging, especially in the context of the following:(1)
a severe phenotype with high morbidity and mortality;(2) the urgency of diagnosis and …

This report represents a summary of the discussions led by the antiseizure treatment
working group of the International League Against Epilepsy (ILAE)/American Epilepsy …

The mechanisms of epileptogenesis in pediatric epileptic syndromes are diverse, and may
involve disturbances of neurodevelopmental trajectories, synaptic homeostasis, and cortical …

The molecular mechanisms leading to infantile epileptic spasm syndrome (IESS) remain
obscure. The only common factor seems to be that the spasms are restricted to a limited …

Neuroinflammation plays a role in the pathology of epilepsy and in cognitive impairment.
Angiotensin II (AII) and the angiotensin receptor type 1 (AT1) have been shown to regulate …

Epileptic seizures of focal origin are classically considered to arise from a focal
epileptogenic zone and then spread to other brain regions. This is a key concept for …