Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents
HM Zhou, JG Zhang, X Zhang, Q Li - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …
contribute to tumor progression and therapy resistance. However, the underlying processes …
Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma
J Feng, J Li, L Wu, Q Yu, J Ji, J Wu, W Dai… - Journal of Experimental & …, 2020 - Springer
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
W Tang, Z Chen, W Zhang, Y Cheng, B Zhang… - Signal transduction and …, 2020 - nature.com
Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis
and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC) …
and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC) …
Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis
Y Li, W Yang, Y Zheng, W Dai, J Ji, L Wu… - Journal of Experimental …, 2023 - Springer
Background Sorafenib resistance is a key impediment to successful treatment of patients
with advanced hepatocellular carcinoma (HCC) and recent studies have reported reversal of …
with advanced hepatocellular carcinoma (HCC) and recent studies have reported reversal of …
Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options
Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
Emerging insights into targeted therapy-tolerant persister cells in cancer
HF Cabanos, AN Hata - Cancers, 2021 - mdpi.com
Simple Summary Acquired resistance to molecularly targeted therapies remains a major
challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or …
challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or …
Hypoxia-inducible factors and innate immunity in liver cancer
VWH Yuen, CCL Wong - The Journal of clinical …, 2020 - Am Soc Clin Investig
The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract.
During the development of liver cancer, which is typically driven by chronic inflammation, the …
During the development of liver cancer, which is typically driven by chronic inflammation, the …
Nanomedicine strategies in conquering and utilizing the cancer hypoxia environment
Y Pan, L Liu, X Mou, Y Cai - ACS nano, 2023 - ACS Publications
Cancer with a complex pathological process is a major disease to human welfare. Due to
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …
Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 …
W Li, C Zhou, L Yu, Z Hou, H Liu, L Kong, Y Xu, J He… - Autophagy, 2024 - Taylor & Francis
Bevacizumab plays an important role in the first and second line treatment for metastatic
colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an …
colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an …
USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation
Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific
protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), and the mechanism they …
protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), and the mechanism they …