Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity
following engagement with its ligand PD-L1. Post-translational modifications (PTMs) …

The global burden of cancer continues to rise, underscoring the urgency of developing more
effective and precisely targeted therapies. This comprehensive review explores the …

T-cell protein tyrosine phosphatase (TC-PTP), encoded by PTPN2, has emerged as a
promising target for cancer immunotherapy. TC-PTP deletion in B16 melanoma cells …

Activating mutations in GNAQ/GNA11 occur in over 90% of uveal melanomas (UMs), the
most lethal melanoma subtype; however, targeting these oncogenes has proven …

Lung cancer stands as the leading cause of mortality among all types of tumors, with over
40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 …

Perturbation of protein phosphorylation represents an attractive approach to cancer
treatment. Besides kinase inhibitors, protein phosphatase inhibitors have been shown to …

Maintaining normal cellular behavior is essential for the survival of organisms. One of the
main mechanisms to control cellular behavior is protein phosphorylation. The process of …

Real-time monitoring of biocatalytic-based processes is significantly improved and simplified
when they can be visualized. Visual monitoring can be achieved by integrating a fluorescent …

Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important
role in the regulation of cell proliferation and signal transduction. The catalytic activity of …