[HTML][HTML] Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
[HTML][HTML] Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
[HTML][HTML] Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
[HTML][HTML] The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha‐synuclein and enhance therapy of Parkinson's disease
J Yuan, H Liu, H Zhang, T Wang, Q Zheng… - Advanced …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
[HTML][HTML] The immunology of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
[HTML][HTML] Iron, neuroinflammation and neurodegeneration
RJ Ward, DT Dexter, RR Crichton - International journal of molecular …, 2022 - mdpi.com
Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins
or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to …
or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to …
[HTML][HTML] The reciprocal interactions between microglia and T cells in Parkinson's disease: a double-edged sword
Y Xu, Y Li, C Wang, T Han, H Liu, L Sun, J Hong… - Journal of …, 2023 - Springer
In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are
overactivated. Overactivation of these immune cells exacerbates the disease process and …
overactivated. Overactivation of these immune cells exacerbates the disease process and …
[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …