Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR …
Guided by the pharmacophoric features of both EGFR and VEGFR-2 antagonists, two novel
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
[HTML][HTML] Multi-step in silico discovery of natural drugs against COVID-19 targeting main protease
In continuation of our antecedent work against COVID-19, three natural compounds, namely,
Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the …
Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the …
[HTML][HTML] A multistage in silico study of natural potential inhibitors targeting SARS-CoV-2 main protease
Among a group of 310 natural antiviral natural metabolites, our team identified three
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …
[HTML][HTML] The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Corresponding to the reported features of anti-VEGFR-2-approved compounds, a new 1 H-
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
[HTML][HTML] Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2, 4-diones targeting VEGFR-2 and apoptosis …
We report herein, the design and synthesis of thiazolidine-2, 4-diones derivatives as new
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
[HTML][HTML] New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic
theobromine-derived compound was designed to interact with the catalytic pocket of EGFR …
theobromine-derived compound was designed to interact with the catalytic pocket of EGFR …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative
In agreement with the general features of VEGFR-2 inhibitors, a new naphthalene analog
(compound 7) has been designed and synthesized. The inhibitory potential of compound 7 …
(compound 7) has been designed and synthesized. The inhibitory potential of compound 7 …
[HTML][HTML] Multi-phase in silico discovery of potential SARS-CoV-2 RNA-dependent RNA polymerase inhibitors among 3009 clinical and FDA-approved related drugs
Proceeding our prior studies of SARS-CoV-2, the inhibitory potential against SARS-CoV-2
RNA-dependent RNA polymerase (RdRp) has been investigated for a collection of 3009 …
RNA-dependent RNA polymerase (RdRp) has been investigated for a collection of 3009 …