The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …

CRISPR/Cas9 delivery strategies with engineered extracellular vesicles

Y Lu, K Godbout, G Lamothe, JP Tremblay - Molecular Therapy-Nucleic …, 2023 - cell.com
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the clustered regularly interspaced short …

Extracellular vesicles and their roles in the tumor immune microenvironment

A Reale, T Khong, A Spencer - Journal of Clinical Medicine, 2022 - mdpi.com
Tumor cells actively incorporate molecules (eg, proteins, lipids, RNA) into particles named
extracellular vesicles (EVs). Several groups have demonstrated that EVs can be transferred …

Advances in purification, modification, and application of extracellular vesicles for novel clinical treatments

Y Matsuzaka, R Yashiro - Membranes, 2022 - mdpi.com
Extracellular vesicles (EV) are membrane vesicles surrounded by a lipid bilayer membrane
and include microvesicles, apoptotic bodies, exosomes, and exomeres. Exosome …

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

C Bourreau, L Treps, S Faure, D Fradin… - Pharmacology & …, 2023 - Elsevier
While new targeted therapies have considerably changed the treatment and prognosis of
non-small cell lung cancer (NSCLC), they are frequently unsuccessful due to primary or …

Pathological and therapeutic significance of tumor-derived extracellular vesicles in cancer cell migration and metastasis

GL Liguori, V Kralj-Iglič - Cancers, 2023 - mdpi.com
Simple Summary Cancer metastasis accounts for almost 90% of cancer deaths worldwide.
The efficiency of current surgical, radiotherapeutic, and chemotherapeutic approaches is …

Activated T cell-derived exosomes for targeted delivery of AXL-siRNA loaded paclitaxel-poly-L-lysine prodrug to overcome drug resistance in triple-negative breast …

C Chen, M Shen, X Wan, L Sheng, Y He, M Xu… - Chemical Engineering …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) still lacks effective treatment options due to tumor
heterogeneity and immunosuppressive microenvironment caused chemoimmunotherapy …

Tumor-derived exosomes and the role of liquid biopsy in human papillomavirus oropharyngeal squamous cell carcinoma

MM Allevato, JD Smith, MJ Brenner… - The Cancer …, 2023 - journals.lww.com
The global incidence of human papillomavirus–positive (HPV+) head and neck squamous
cell carcinoma (HNSCC) has surged in recent decades, with HPV+ HNSCC accounting for> …

Cancer-derived extracellular vesicles as biomarkers for cutaneous squamous cell carcinoma: A systematic review

ITL Lee, CH Shen, FC Tsai, CB Chen, KSK Ma - Cancers, 2022 - mdpi.com
Simple Summary Biomarkers including DNA, RNA, and surface-associated proteins in tumor-
derived extracellular vesicles promote accurate clinical diagnosis and indicate the prognosis …

Phospholipid-membrane-based nanovesicles acting as vaccines for tumor immunotherapy: Classification, mechanisms and applications

W Chen, Y Wu, J Deng, Z Yang, J Chen, Q Tan, M Guo… - Pharmaceutics, 2022 - mdpi.com
Membrane vesicles, a group of nano-or microsized vesicles, can be internalized or interact
with the recipient cells, depending on their parental cells, size, structure and content …