The roles of opioid receptors in pain and addiction have been extensively studied, but their
function in mood disorders has received less attention. Accumulating evidence from animal …

Rationale Research on adolescence and drug abuse increased substantially in the past
decade. However, drug-addiction-related behaviors following stressful experiences during …

Autism is a behaviourally defined disorder including attenuated or abnormal social
interaction and communication, as well as aberrant repetitive behaviour, with symptoms …

The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

Background Mouse models of social behavior fail to account for volitional aspects of social
interaction, and current neurobiological investigation of social behavior is performed almost …

Background Opioid discontinuation generates a withdrawal syndrome marked by increased
negative affect. Increased symptoms of anxiety and dysphoria during opioid discontinuation …

Background Experiences of abuse and neglect during childhood are major predictors of the
emergence of depressive and suicidal behaviors throughout life. The underlying biological …

Rationale Social factors are important determinants of drug dependence and relapse.
Objectives We reviewed pre-clinical literature examining the role of social experiences from …

Opioid addiction is a chronic and relapsing mental health disorder. However, only some
individuals exposed to opioids, either recreationally or during the course of pain …

Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …