Executive summary The Stanford–Lancet Commission on the North American Opioid Crisis
was formed in response to soaring opioid-related morbidity and mortality in the USA and …

Importance Craving, which is a strong desire for drugs, is a newDSM-5diagnostic criterion
for substance use disorders (SUDs), which are the most prevalent, costly, and deadly forms …

Drug addiction is a public health crisis for which new treatments are urgently needed. In rare
cases, regional brain damage can lead to addiction remission. These cases may be used to …

The view that substance addiction is a brain disease, although widely accepted in the
neuroscience community, has become subject to acerbic criticism in recent years. These …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Social media companies commonly design their platforms in a way that renders them
addictive. Some governments have declared internet addiction a major public health …

Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Peer recovery support services (PRSS) are increasingly being employed in a range of
clinical settings to assist individuals with substance use disorder (SUD) and co-occurring …

Alcohol use disorder (AUD) is among the most prevalent psychiatric disorders and is
associated with enormous public health costs. Although AUD and other addictive behaviors …

Importance Medication treatment for opioid use disorder (MOUD) is efficacious, but
comorbid stimulant use and other behavioral health problems often undermine efficacy …