Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy

S Pahlavanneshan, A Sayadmanesh… - Journal of …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …

[HTML][HTML] The critical role of Toll-like receptor-mediated signaling in cancer immunotherapy

X Chen, Y Zhang, Y Fu - Medicine in Drug Discovery, 2022 - Elsevier
Toll-like receptors (TLR) play a dual regulatory role in the tumor microenvironment (TME).
TLR agonists (TLRa) elicit both innate and adaptive immune responses to achieve anti …

Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity

JA Malik, G Kaur, JN Agrewala - International Journal of Biological …, 2023 - Elsevier
Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Nano-adjuvants and immune agonists promote antitumor immunity of peptide amphiphiles

H Yan, G Lin, Z Liu, F Gu, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Immunostimulatory cues play an important role in priming antitumor immunity and promoting
the efficacy of subunit cancer vaccines. However, the clinical use of many …

[HTML][HTML] Glucocorticoid-induced leucine zipper-mediated TLR2 downregulation accounts for reduced neutrophil activity following acute DEX treatment

E Ricci, E Roselletti, M Gentili, S Sabbatini, S Perito… - Cells, 2021 - mdpi.com
Glucocorticoids are the most powerful anti-inflammatory and immunosuppressive
pharmacological drugs available, despite their adverse effects. Glucocorticoid-induced …

Post‐transcriptional control of T‐cell cytokine production: Implications for cancer therapy

JJ Freen‐van Heeren - Immunology, 2021 - Wiley Online Library
As part of the adaptive immune system, T cells are vital for the eradication of infected and
malignantly transformed cells. To perform their protective function, T cells produce effector …

[HTML][HTML] AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC

G Thomas, K Hirter, E Frederick, M Hausburg… - Translational medicine …, 2022 - Springer
Background Dysregulation of antiviral immunity has been implicated in the progression of
acute respiratory syndrome coronavirus 2 infection into severe cases of coronavirus disease …

Posttranscriptional Events Orchestrate Immune Homeostasis of CD8+ T Cells

JJ Freen-van Heeren - Immune Homeostasis: Methods and Protocols, 2024 - Springer
Maintaining immune homeostasis is instrumental for host health. Immune cells, such as T
cells, are instrumental for the eradication of pathogenic bacteria, fungi and viruses …

[HTML][HTML] Screening of periodontitis-related genes and immune cells based on an integrated bioinformatics analysis

Q Ban, X Ling, H Ding, J Meng, Y Li… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background Periodontitis is a serious health issue; however, there are few reports on
periodontitis and immune related. The study sought to analyze differences in gene …

The inhibition of CD4+ T cell proinflammatory response by lactic acid is independent of monocarboxylate transporter 1

P Yang, Y Sun, M Zhang, L Hu, X Wang… - Scandinavian …, 2021 - Wiley Online Library
Lactic acid was originally a by‐product of glucose metabolism, but many studies have
shown that lactic acid plays a vital role in regulating immune cell polarization, differentiation …