Simple Summary Melanoma is the third most common type of skin cancer. Melanoma is a
heterogeneous tumor, composed of genetically divergent subpopulations. These …

Ultraviolet (UV) radiation plays a crucial role in the development of melanoma and non-
melanoma skin cancers. The types of UV radiation are differentiated by wavelength: UVA …

Extracellular vesicles (EVs) are important mediators of communication between cells. Here,
we reveal a new mode of intercellular communication by melanosomes, large EVs secreted …

Abstract Whole Slide Images (WSIs) have significantly advanced the field of pathology by
providing highly detailed views of tissue samples. Integrating Deep Learning (DL) into this …

The study aims to investigate various aspects of synthesized mono-chalcone compounds 5
and 8 concerning breast cancer, including network pharmacology, molecular docking …

β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism
by removing β-galactosyl moieties from β-galactosyl ceramide and β-galactosyl …

Most anti-cancer modalities are designed to directly kill cancer cells deploying mechanisms
of action (MOAs) centered on the presence of a precise target on cancer cells. The efficacy …

In the last decade, targeted therapies have shown rapid advancement in biliary tract cancer
(BTC). Today, many targeted agents are available and under investigation for patients with …

Skin cancer (SC) poses a global threat to the healthcare system and is expected to increase
significantly over the next two decades if not diagnosed at an early stage. Early diagnosis is …

Melanoma, a malignant neoplasm originating from melanocytes, stands as one of the most
prevalent cancers globally, ranking fifth in terms of estimated new cases in recent years. Its …