Epigenetics as a mediator of plasticity in cancer
AP Feinberg, A Levchenko - Science, 2023 - science.org
The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
Computational network biology: data, models, and applications
Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …
biological information from the network concepts are of great significance. Benefiting from …
[HTML][HTML] Quantification of tumor heterogeneity: from data acquisition to metric generation
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
In silico polypharmacology of natural products
Natural products with polypharmacological profiles have demonstrated promise as novel
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
A new view of activating mutations in cancer
R Nussinov, CJ Tsai, H Jang - Cancer research, 2022 - AACR
A vast effort has been invested in the identification of driver mutations of cancer. However,
recent studies and observations call into question whether the activating mutations or the …
recent studies and observations call into question whether the activating mutations or the …
Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era
Advances in next-generation sequencing technologies have generated the data supporting
a large volume of somatic alterations in several national and international cancer genome …
a large volume of somatic alterations in several national and international cancer genome …
In silico oncology drug repositioning and polypharmacology
F Cheng - Cancer bioinformatics, 2019 - Springer
Network-aided in silico approaches have been widely used for prediction of drug-target
interactions and evaluation of drug safety to increase the clinical efficiency and productivity …
interactions and evaluation of drug safety to increase the clinical efficiency and productivity …
[HTML][HTML] Differential co-expression analyses allow the identification of critical signalling pathways altered during tumour transformation and progression
Biological systems respond to perturbations through the rewiring of molecular interactions,
organised in gene regulatory networks (GRNs). Among these, the increasingly high …
organised in gene regulatory networks (GRNs). Among these, the increasingly high …
[HTML][HTML] Multi-omic data interpretation to repurpose subtype specific drug candidates for breast cancer
Triple-negative breast cancer (TNBC), which is largely synonymous with the basal-like
molecular subtype, is the 5th leading cause of cancer deaths for women in the United States …
molecular subtype, is the 5th leading cause of cancer deaths for women in the United States …
[HTML][HTML] Measuring intratumor heterogeneity by network entropy using RNA-seq data
Intratumor heterogeneity (ITH) is observed at different stages of tumor progression,
metastasis and reouccurence, which can be important for clinical applications. We used …
metastasis and reouccurence, which can be important for clinical applications. We used …