Cell signal transduction is a non-equilibrium process characterized by the reaction cascade.
This study aims to quantify and compare signal transduction cascades using a model of …

Community detection or clustering is a crucial task for understanding the structure of
complex systems. In some networks, nodes are permitted to be linked by either “positive” or …

Chapter 3 through Chap. 11 introduces the current status of clinical applications of
polypharmacology to disease therapy. This chapter will describe the applications of …

Cell signal transduction is an example of a nonequilibrium phenomenon. In this study, a
nonequilibrium nonlinear thermodynamic model was formulated. First, we obtained a …

Tumor development is a process involving loss of the differentiation phenotype and
acquisition of stem-like characteristics, which is driven by intracellular rewiring of signaling …

A simple, label-free cytometry technique is introduced. It is based on the analysis of the
fluctuation of image Gray Level Information Entropy (GLIE) which is shown to reflect …

One of the most challenging problems in biomedicine and genomics is the identification of
disease biomarkers. In this study, proteomics data from seven major cancers were used to …

A model of signal transduction from the perspective of informational thermodynamics has
been reported in recent studies, and several important achievements have been obtained …

Background: Complexity and dynamicity of biological events is a reason to use
comprehensive and holistic approaches to deal with their difficulty. Currently with advances …

Multi-class datasets often comprise samples of various classes united under a common
research context. Based on this limited amount of data one searches for concepts that …