Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Immune system defects are at the center of aging and a range of diseases. Here, we show
that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell …

With many caveats to the traditional vertebrate species pertaining to biogerontology
investigations, it has been suggested that a most informative model is the one which: 1) …

Methionine restriction extends the lifespan of various model organisms. Limiting S-adenosyl-
methionine (SAM) synthesis, the first metabolic reaction of dietary methionine, extends …

Restricted dietary intakes of protein or essential amino acids tend to slow aging and boost
lifespan in rodents, presumably because they downregulate IGF-I/Akt/mTORC1 signaling …

Experimental, clinical, and epidemiological findings support the concept of developmental
origins of health and disease (DOHAD), suggesting that early-life hormonal influences …

Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an
increase in either the size and/or number of its characteristic cell type, the adipocyte. As one …

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A
decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and …

As a tool for measuring the aging process, life span has been invaluable in dissecting the
genes that modulate longevity. Studies over the past few decades have identified several …

Abstract Significance: Hydrogen sulfide (H2S) at the right concentration is associated with
numerous health benefits in experimental organisms, ranging from protection from …